The cell cycle and cell death. Kinetics of Biological Reactions

The course describes in details the autophagy, cell cycle characterization and features, basic mechanism of necrosis. This course includes a description of the basic mechanisms of cell death. It shows that identification of the type of cell death is very important when studying the effect of nanomaterials on biological objects (types of cell death differ in their parameters and the effect on cell metabolism, intercellular space, surrounding tissues). The course describes in detail additional changes occurring in the cell and the body as a result of the cell death processes development. It is also shows that the development of apoptosis, necrosis, and autophagy can be induced by the influence (or treatment) of nanomaterials on cellular structures. A significant part of the course is devoted to the description of the cell cycle, because cell condition is very important for the regulation of cellular processes. The course describes the role of caspases, Bcl-2 family proteins and other molecules in cell death regulation. This course describes in details the kinetics of biological reactions, usage of the experimental and theoretical study of kinetics of biochemical reactions, kinetics of enzyme reactions. Protein folding and proteostasis processes are described. A significant part of the course is devoted to the description of the basic principles and mechanisms of protein functionalization. Phosphorylation is described as one of the important ways to regulate the activity of proteins.

The purpose of studying the course is the mastery of the basic information and principles of cell death and basic principles of kinetics of biological reactions for further use by other disciplines of natural science content.

Lecturers:

Dr. Deniz Kuscuoglu, University Hospital RWTH Aachen, Clinic of Gastroenterology, Metabolic Diseases and Internal Medicine Intensive Care (Medical Clinic III).

Dr. Yuriy Pankratov, School of Life Sciences, The University of Warwick, Coventry, United Kingdom.

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Competence of educational standard

• Ability for self-organization and self-education
• Ability for time management and self-management for continuing studies
• Ability to use the acquired knowledge for to select appropriate techniques to solve a scientific problem
• Ability to solve standard tasks of professional activity on the basis of information and bibliographic culture using information and communication techniques.
• Ability to adapt to a change in the scientific profile of their professional activities, socio-cultural and social conditions of activity.
• Ability to independently establish specific tasks of scientific research in the field of physics and solve them with the help of modern equipment and information technologies with the use of the newest domestic and foreign experience.

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Трудоемкость дисциплины составляет 2 ЗЕТ (72 часа)