Чему вы научитесь
- The course is devoted to particular questions of enzymology. The cause of hereditary enzymopathies is a genetically determined deficiency or complete absence of enzyme synthesis. We tried to make this course as modern as possible. Find out how in hereditary enzymopathies, certain metabolic pathways are disrupted, their end products are deficient and intermediates accumulate, which leads to clinical manifestations. We will acquaint you with the features of the course of hereditary enzymopathies and the presence of a latent period when the disease is not clinically manifested, but can be suspected or established on the basis of biochemical studies
О курсе
Particular Issues of Medical Enzymology
1.Enzymes: General understanding.
The first set of the course introduces you to enzymes as biological catalysts. We are talking with you about the classification of enzymes, about their structure. This part describes in detail the functions of enzymes, how the ways of their activity regulation, provides the detailed information on inhibitors, types of inhibition. We prepare you to understand how inherited defects of a particular enzyme can affect the overall metabolic rate and how enzymes can be used for diagnostic and therapeutic purposes.
2. The inherited defects of enzymes of carbohydrate metabolism
Defects of enzymes involved in the synthesis and breakdown of glycogen. Various types of glycogenosis. Hereditary defects in enzymes of metabolism of galactose and fructose. Pyruvate kinase deficiency. Different types of mucopolysaccharidoses
3. The inherited defects of enzymes of lipid metabolism
The functions of lecithin-cholesterol acyltransferase (LCAT) and diseases associated with defects in this enzyme. Hereditary defects of biotinidase and their manifestations. Diseases associated with a deficiency of the enzyme acyl-CoA dehydrogenase. Various types of sphingolipidosis. Refsum disease. Diseases associated with lipoprotein lipase deficiency
4. The inherited defects of enzymes of amino acid metabolism
The fourth chapter presents diseases associated with defects in the enzymes of the urea cycle. Phenylketonuria as a disease associated with a defect in phenylalanine conversion. Alkaptonuria, tyrosinemia and albinism. Homocystinuria. Maple syrup urine disease
5. Enzymes for cancer treatment
The fifth chapter talks about the use of enzymes in the treatment of cancer. Asparaginase: its discovery, mechanism of action, and clinical use. How to increase the efficiency and reduce the toxicity of enzyme preparations. Lysine oxidase has a dual mechanism of action. Methionidase. Prospects for use.
Each section contains:
- Video lecture
- Theoretical materials
- Didactic materials
- Information resources
- Knowledge control
- Opinion exchange
Для кого этот курс
Начальные требования
You will need a basic knowledge of inorganic and organic chemistry, biology, physiology, and biochemistry. Don't let that scare you! We have tried to make the course as accessible as possible for students. The information in the course is presented in a consistent and simple manner. We will help you understand complex topics and understand everything to the end.