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Finding Hidden Messages in DNA (Bioinformatics I)

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About the course

A genome may look like an incomprehensible string of the letters A, C, G, and T. Yet hidden in the three billion nucleotides of your genome is a secret language. This course offers an introduction to how we can start to understand this language by using algorithms to find hidden messages in DNA.

What do these hidden messages say?  In the first chapter of the course, hidden DNA messages indicate where a bacterium starts replicating its genome, a problem with applications in genetic engineering and beyond. In the second chapter, hidden DNA messages tell us how organisms know whether it is day or night as well as how the bacterium causing tuberculosis is able to hide from antibiotics. We will see how randomized algorithms, which toss coins and roll dice, can be used to find these messages.

Each of the two topics in the course builds the algorithmic knowledge required to address this challenge. In the end of the course, you will be able to apply popular bioinformatics software tools for finding regulatory motifs in experimental data sets and solve our Bioinformatics Application Challenge.

The Bioinformatics Specialization to which this class belongs covers exactly the same material as the core bioinformatics class in the "Bioinformatics and Systems Biology" program at the University of California at San Diego, one of the top bioinformatics programs in the world. In other words, you will have exactly the same lectures and homework assignments as students at UCSD. Moreover, many leading universities have adopted this material in their offline classes. Our goal is to provide you with the same high-quality materials that these students study in their offline classes.

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Learn how to find the "hidden messages" in DNA that tell bacteria how to replicate their genome and that help the cell know what time it is.

Open date:
Mar 6, 2016
Last deadline:
Apr 18, 2016
Workload:
4-10 hours/week
Expected time to complete:
23 hours
Language:
English
Certificate:
Not issuing

About the course

A genome may look like an incomprehensible string of the letters A, C, G, and T. Yet hidden in the three billion nucleotides of your genome is a secret language. This course offers an introduction to how we can start to understand this language by using algorithms to find hidden messages in DNA.

What do these hidden messages say?  In the first chapter of the course, hidden DNA messages indicate where a bacterium starts replicating its genome, a problem with applications in genetic engineering and beyond. In the second chapter, hidden DNA messages tell us how organisms know whether it is day or night as well as how the bacterium causing tuberculosis is able to hide from antibiotics. We will see how randomized algorithms, which toss coins and roll dice, can be used to find these messages.

Each of the two topics in the course builds the algorithmic knowledge required to address this challenge. In the end of the course, you will be able to apply popular bioinformatics software tools for finding regulatory motifs in experimental data sets and solve our Bioinformatics Application Challenge.

The Bioinformatics Specialization to which this class belongs covers exactly the same material as the core bioinformatics class in the "Bioinformatics and Systems Biology" program at the University of California at San Diego, one of the top bioinformatics programs in the world. In other words, you will have exactly the same lectures and homework assignments as students at UCSD. Moreover, many leading universities have adopted this material in their offline classes. Our goal is to provide you with the same high-quality materials that these students study in their offline classes.